… Using the cisplatin–DNA DELFIA and electron microscopy with colloidal gold … we have
shown that the preferential cisplatin–DNA adduct formation in mtDNA of CHO cells is likely to be a …

… Cisplatin-DNA adducts were measured in DNA from nuclear … the formation and removal of
DNA adducts in mitochondria. … a low membrane potential is associated with low accumulation …

… Mitochondrial DNA (mtDNA), which lacks histones,103 has … A study in Chinese hamster
ovary cells used a dissociation-… The preference for mtDNA was later attributed both to higher …

… DNA damage as an initial step of the nucleotide excision and … It could preferentially bind
to DNA–cisplatin adducts in rRNA … to the DNA of Chinese hamster ovary cells treated with …

… , were also found to be preferentially toxic to hypoxic cells, up to four times … Sequence of
action of DNA excision repair … may bind to monofunctional cisplatin-DNA adducts, preventing the …

… of Pt–damaged DNA without removal of the adduct. In addition, … of the cytotoxicity of
cisplatin-DNA adducts has been proposed … Thus, HMG1 may bind preferentially to cisplatin …

… the level of ERCC1, it decreased its excision repair function. In … caused by the excision of
cisplatin-DNA adducts has been … MT-3 and Pt(II) is kinetically preferred [81]. The authors further …

… some sites in DNA are preferentially modified and therefore … like nitrosoureas, DNA repair
pathways that remove only … cytotoxicity of cisplatin in Chinese hamster ovary cells at exactly the …

… interactions due to their relevance to the cisplatin-DNA adducts … than nuclear DNA [277],
depletion of mitochondrial DNA … repair of DNA cross-links in chinese hamster ovary cells treated …

… This suggests that XPC plays a role in initiating cisplatin DNA … could preferentially target
mitochondrial DNA sequences. … of DNA cross-links in chinese hamster ovary cells treated with …